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The sphingosine-1-phosphate receptor 1 (S1PR1) is an important biomarker for imaging inflammation in the central nervous system (CNS). Herein, we report our recent evaluation of four 18 F-labeled S1PR1 tracers ( 18 F-TZ43113, 18 F-TZ35104, 18 F-TZ4877, and 18 F-TZ4881) in a rat model of multiple sclerosis (MS).

In vivo Characterization of Four 18F-Labeled S1PR1 Tracers for Neuroinflammation