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Non-invasive techniques allowing quantitative determination of the functional liver mass are of great interest for patient management in a variety of clinical settings. Recently, we presented [ 68 Ga]DTPA-GSA to target the hepatic asialoglycoprotein receptor for this purpose. Here, we introduce [ 68 Ga]NOTA-GSA to improve metabolic stability of the radiopharmaceutical and compare the imaging properties with [ 68 Ga]DTPA-GSA.

[68Ga]NOTA-Galactosyl Human Serum Albumin: a Tracer for Liver Function Imaging with Improved Stability