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[ 11 C]Preladenant was developed as a novel adenosine A 2A receptor PET radioligand. The aim of this study was to determine the radiation dosimetry of [ 11 C]preladenant and to investigate whether dosimetry estimation based on organ harvesting can be replaced by positron emission tomography (PET)/x-ray computed tomography (CT) imaging in rats.

Radiation Dosimetry of a Novel Adenosine A2A Receptor Radioligand [11C]Preladenant Based on PET/CT Imaging and Ex Vivo Biodistribution in Rats