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Purpose   Studies of patients with ulcerative colitis (UC) report that reduced clinical symptoms and endoscopic activity predict better health-related quality of life (HRQoL). However, no study has examined the joint and unique associations of clinical and endoscopic activity with HRQoL, nor of histologic inflammation and HRQoL. These post hoc analyses evaluated whether reduced clinical, endoscopic, and histologic disease activity were uniquely associated with improved HRQoL for adults with active mild-to-moderate UC receiving once-daily 4.8 g/day multimatrix mesalazine for 8 weeks.    Methods  Assessments at baseline and week 8 (i.e., treatment completion) included clinical and endoscopic activity (modified UC-Disease Activity Index), histology (Geboes scoring), and HRQoL (Short Inflammatory Bowel Disease Questionnaire [SIBDQ]; SF-12v2 ®  Health Survey [SF-12v2]). Associations among each type of disease activity and HRQoL were examined by correlations and by mean changes in SIBDQ and SF-12v2 scores between disease activity subgroups (e.g., achievement of clinical remission; mucosal healing). Regression models estimated unique variance in HRQoL accounted by each type of disease activity.    Results  Within the analysis sample ( n  = 717), patients with reduced clinical and endoscopic activity had significantly larger improvements in all HRQoL domains ( p  < 0.001), as did patients in both endoscopic and clinical remission compared to patients in endoscopic remission only ( p  < 0.05). Patients with histologic activity post-treatment scored significantly worse on all HRQoL domains than patients with no activity ( p  < 0.05). Correlations and regression models found that decreases in clinical and endoscopic activity were associated with improvements in HRQoL domain scores.    Conclusions  Clinical symptoms and mucosal health have separable, distinct impacts on UC patients’ HRQoL.    Supplementary Information  The online version of this article (10.1007/s11136-021-02787-4) contains supplementary material, which is available to authorized users.

quality of life research

The impact of clinical symptoms and endoscopic and histologic disease activity on health-related quality of life in patients with ulcerative colitis following treatment with multimatrix mesalazine