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Purpose Study on curcumin dissolved in natural deep eutectic solvents (NADES)was aimed at exploiting their beneficial properties as drug carriers. MethodsThe concentration of dissolved curcumin in NADES was measured. Simulatedgastrointestinal fluids were used to determine the concentration of curcuminand quantum chemistry computations were performed for clarifying the origin ofcurcumin solubility enhancement in NADES. Results NADES comprising cholinechloride and glycerol had the highest potential for curcumin dissolution. Thissystem was also successfully applied as an extraction medium for obtainingcurcuminoids from natural sources, as well as an effective stabilizerpreventing curcumin degradation from sunlight. The solubility of curcumin insimulated gastrointestinal fluids revealed that the significant increase ofbioavailability takes place in the small intestinal fluid. ConclusionsSuspension of curcumin in NADES offers beneficial properties of this new liquiddrug formulation starting from excreting from natural sources, through safestorage and ending on the final administration route. Therefore, there is apossibility of using a one-step process with this medium. The performed quantumchemistry computations clearly indicated the origin of the enhanced solubilityof curcumin in NADES in the presence of intestinal fluids. Directintermolecular contacts leading to hetero-molecular pairs with choline chlorideand glycerol are responsible for elevating the bulk concentration of curcumin.Choline chloride plays a dominant role in the system and the complexes formedwith curcumin are the most stable among all possible homo- and hetero-molecularpairs that can be found in NADES-curcumin systems.

Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin