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TiO$_{2}$ nanoparticles (NPs) have unique photocatalytic properties, whichare used in food industries, medicine, biosensorics, and solar energyconversion. Since the toxic properties of TiO$_{2}$ NPs have beeninsufficiently studied, additional information on the molecular mechanisms oftheir biological action on the structure and stability of biologicalmacromolecules is needed, especially concerning DNA. In this work exploitingthe differential UV-visible spectroscopy, the effect of the heating (from 20till 90 $^0$C) and concentration of TiO$_{2}$ NPs ((1-3)$\times$10$^-$$^4$ M)on a conformation of native DNA adsorbed on TiO$_{2}$ NPs in a buffer solution(pH 5) is studied. Analysis of dynamic light scattering (DLS) data for theDNA:TiO$_{2}$ NPs suspension revealed that when the temperature increases theseparated DNA:TiO$_{2}$ NP nanoassemblies form nanoaggregates. Correlationbetween the thermal dependency of the DLS data and thermal DNA denaturationmeasurements indicated that the appearance of the single-stranded unwoundregions in double-stranded DNA in the suspension with temperature rise promotesthe effective formation of the DNA:TiO$_{2}$ NPs nanoaggregates.

DNA-TiO$_{2}$ nanoparticle nanoassembies: effect of temperature and nanoparticles concentration on aggregation