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Gastric cancer is one of the most common worldwide types of cancer. It is a multifactorial disease and both environmental and genetic factors play an important role in its etiology. Evaluation of the relative expression level of  NFKB2  gene in two groups of patients: peptic ulcer and gastric cancer and its role in the pathomechanism of these diseases was the aim of this study. RNA was isolated from: 79 samples of peptic ulcer, 22 gastric cancer and 11 control tissue. The real-time PCR technique was used to study the expression of  NFKB2  gene. The relative expression level of  NFKB2  gene was a variable in all three studied groups. The relative  NFKB2  gene expression depends on the type of a disease. Peptic ulcer cases showed the increased relative  NFKB2  gene expression to control group ( p  = 0.0000). Cancer cases presented decreased relative  NFKB2  gene expression to normal stomach tissue ( p  = 0.0183). There are statistically important differences in the investigated gene expression between peptic ulcer, where the expression level is higher comparing to gastric cancer and control tissue which confirmed that such an activation is connected with an inflammatory process. The relative expression level of  NFKB2  is decreased in cancer cases as opposed to control tissue and peptic ulcer cases which could suggest that during carcinogenesis of gastric cancer inhibition of NF-kB pathway takes place which could be a promising factor for patients.

NFKB2 gene expression in patients with peptic ulcer diseases and gastric cancer