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The compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane-1,3-dione  3  with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. The chemical structures of these compounds were confirmed by various spectroscopic methods such as (IR,  1 H-NMR,  13 C-NMR, mass spectra and elemental analyses). The prepared compounds were screened in vitro for their anti-microbial activity against some species of Gram-positive bacteria  (Staphylococcus aureus  and  Bacillus subtilis)  and Gram-negative bacteria ( Escherichia coli  and  Pseudomonas aeuroginosa ). Anti-fungal activities of the compounds were tested against yeast and mycelial fungi, Candida albicans  and  Aspergillus flavus . The antimicrobial activity of this series was showed either weak or moderate activities. Graphic abstract

molecular diversity

Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives