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Due to its favorable decay properties, the non-standard radionuclide  45 Ti is a promising PET isotope for tumor imaging. Additionally, titanium complexes are widely used as anti-tumor agents and  45 Ti could be used to study their in vivo distribution and metabolic fate. However, although  45 Ti can be obtained using the  45 Sc(p,n) 45 Ti nuclear reaction its facile production is offset by the high oxophilicity and hydrolytic instability of Ti 4+  ions in aqueous solutions, which complicate recovery from the irradiated Sc matrix. Most available  45 Ti recovery procedures rely on ion exchange chromatography or solvent extraction techniques which are time-consuming, produce large final elution volumes, or, in case of solvent extraction, cannot easily be automated. Thus a more widespread application of  45 Ti for PET imaging has been hampered. Here, we describe a novel, solvent-free approach for recovery of  45 Ti that involves formation of [ 45 Ti]TiCl 4  by heating of an irradiated Sc target in a gas stream of chlorine, followed by thermochromatographic separation of the volatile radiometal chloride from co-produced scandium chloride and trapping of [ 45 Ti]TiCl 4  in a glass vial at − 78 °C. The recovery of  45 Ti amounted to 76 ± 5% (n = 5) and the radionuclidic purity was determined to be &gt; 99%. After trapping, the [ 45 Ti]TiCl 4  could be directly used for  45 Ti-radiolabeling, as demonstrated by the successful radiosynthesis of [ 45 Ti][Ti(2,4-salan)].

Thermochromatographic separation of 45Ti and subsequent radiosynthesis of [45Ti]salan