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The Agent-Empowered HealthCare Systems Special Issue includes a selection of papers that provide discussion on the most recent and innovative work regarding the study and application of agent-based technology to healthcare. Healthcare facilities faces now diverse and complex everyday challenges, ranging from equipment and drug inventory management to patient clinical record and follow-up management, or even patient monitoring in either a hospital or home environment, and patient transportation scheduling. At the same time, the progressive maturity of agent technology methodologies and tools has led to the development of applications in many complex real-world domains. Covering a wide spectrum of research areas, this special issue intends to bring together communities from Computer Science and Agent-Based Systems and Clinicians working on Healthcare, Medicine and Biomedicine, providing a presentation and discussion forum for researchers in the area, highlighting innovative approaches, multidisciplinary works, and defining future research directions. The special issue accepted submission of paper concerning the use of agents encompassed in the healthcare context e.g. ranging from equipment and drug inventory management to patient clinical record and follow-up management, or even patient monitoring in either a hospital or home environment, and patient transportation scheduling. Topics of interest included: Medical Data Management, Information Retrieval and Knowledge Management, Agent-based Information Provider Services, Remote Care, and Telemedicine, Mobile

Special Issue JOMS – Journal of Medical Systems, 2016 on Agent-Empowered HealthCare Systems