English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Fluorescence probes that selectively image cadmium are useful for detecting and tracking the amount of Cd 2+ in cells and tissues. In this study, we designed and synthesized a novel Cd 2+ fluorescence probe based on the pyridine-pyrimidine structure, 4-(methylsulfanyl)-6-(pyridin-2-yl)pyrimidin-2-amine (3), as a low-molecular-weight fluorescence probe for Cd 2+ . Compound 3 could successfully discriminate between Cd 2+ and Zn 2+ and exhibited a highly selective turn-on response toward Cd 2+ over biologically related metal ions. The dissociation constant (K d ) and the limit of detection (LOD) of 5.4 × 10 - 6  mol L - 1 and 4.4 × 10 - 7  mol L - 1 , respectively, were calculated using fluorescence titration experiments. Studies with closely related analogs showed that the bis-heterocyclic moiety of 3 acted as both a coordination site for Cd 2+ and a fluorophore. Further, the methylsulfanyl group of compound 3 is essential for achieving selective and sensitive Cd 2+ detection. Fluorescence microscopy studies using living cells revealed that the cell membrane permeability of compound 3 is sufficient to detect intracellular Cd 2+ . These results indicate that novel bis-heterocyclic molecule 3 has considerable potential as a fluorescence probe for Cd 2+ in biological applications.

Selective Cadmium Fluorescence Probe Based on Bis-heterocyclic Molecule and its Imaging in Cells