English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

This paper illustrates an informatic technique for inferring and quantifying the dynamic role of a single intrinsic current in a mechanism of neural bursting activity. We analyze the patterns of the most dominant currents in a model of half-center oscillation in the leech heartbeat central pattern generator. We find that the patterns of dominance change substantially over a cycle, allowing different local reductions to be applied to the model. The result is a hybrid dynamical systems model, which is a piecewise representation of the mechanism combining multiple vector fields and discrete state changes. The simulation of such a model tests explicit hypotheses about the mechanism and is a novel way to retain both mathematical clarity and scientific detail in answering mechanistic questions about a complex model. Several insights into the central mechanism of "escape-release" in the model are elucidated by this analysis and compared with previous studies. The broader application and extension of this technique is also discussed.

Inferring and quantifying the role of an intrinsic current in a mechanism for a half-center bursting oscillation