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Human ARTs have draw heavily upon observation and manipulations on a “micro” scale. Thanks in large measure to the evolution of the light microscope and digital imaging, the secrets of sperm, oocytes and embryos are no longer hidden from view but, rather, broadcast with aplomb throughout the embryology laboratory, on a daily basis. Current clinical practices offer patients an array of procedures that involve probing, injecting, sucking, and cutting our gametes and embryos—all under the skillful eyes of the embryologist and with the intent to achieve a pregnancy for our patients. Thus, ICSI, polar body or blastomere biopsy, assisted hatching et al, collectively reflect the translational incorporation of microscopy and micro scale engineering into the daily practices of human ARTs. So, how distant is the day when, as a matter of scale, ARTs enters the nanoworld?

Nanosurgical interventions in the practice of human ARTs