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Immune checkpoint inhibitors (ICPIs) have revolutionized cancer therapy, although immune-related adverse events (irAEs) remain a serious issue. The clinical characteristics of colitis induced by ICPIs are very similar to inflammatory bowel disease. Recently, cluster of differentiation 8 positive (CD8 + ) lymphocyte infiltration into organs has been associated with the onset of irAEs. The present study compared the histological infiltration of CD8 +  lymphocytes in irAE colitis with that in other colitis.

CD8+ Lymphocyte Infiltration Is a Specific Feature of Colitis Induced by Immune Checkpoint Inhibitors