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Positive energy imbalance and growth factors linked to obesity promote the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (mTOR) pathway. As the obesity-breast cancer associations differ between European American (EA) and African-American (AA) women, we investigated genetic variants in the mTOR pathway and breast cancer risk in these two racial groups.

ccc. cancer causes and control/ccc, cancer causes and control

Genetic variants in the mTOR pathway and interaction with body size and weight gain on breast cancer risk in African-American and European American women