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The basic goal of this study was to synthesize zinc oxide nanoparticles using the  Chelidonium majus  extract and asses their cytotoxic and antimicrobial properties. The synthesized ZnO NPs were characterized by UV-Vis, Scanning Electron Microscopy (SEM) with EDS profile, Fourier Transform Infrared Spectroscopy (FTIR), X-ray diffraction (XRD), Transmission Electron Microscopy (TEM) and Atomic Force Microscopy (AFM). The aforementioned methods confirmed that the size of synthesized ZnO nanoparticles was at the range of 10 nm. The antimicrobial activity of ZnO nanoparticles synthesized using the  Ch. majus  extract was tested against standard strains of bacteria ( Staphylococcus aureus  NCTC 4163,  Pseudomonas aeruginosa  NCTC 6749,  Escherichia coli  ATCC 25922) ,  yeast ( Candida albicans  ATCC 10231), filamentous fungi (molds:  Aspergillus niger  ATCC 16404, dermatophytes:  Trichophyton rubrum  ATCC 28188), clinical strains of bacteria ( Escherichia coli ,  Pseudomonas aeruginosa, Staphylococcus aureus ) and yeast ( Candida albicans ). The study showed that zinc oxide nanoparticles were excellent antimicrobial agents. What is more, biologically synthesized ZnO nanoparticles demonstrate high efficiency in treatment of human non-small cell lung cancer A549.

Cytotoxic and antimicrobial effects of biosynthesized ZnO nanoparticles using of Chelidonium majus extract