English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The COVID-19 pandemic has resulted in more than 30.35 million infections and9, 50, 625 deaths in 212 countries over the last few months. Different drugintervention acting at multiple stages of pathogenesis of COVID-19 cansubstantially reduce the infection induced mortality. The current within-hostmathematical modeling studies deals with the optimal drug regimen and theefficacy of combined therapy in treatment of COVID-19. The drugs/interventionsconsidered include Arbidol, Remdesivir, Inteferon (INF) andLopinavir/Ritonavir. It is concluded that these drug interventions whenadministered individually or in combination reduce the infected cells and viralload. Four scenarios involving administration of single drug intervention, twodrug interventions, three drug interventions and all the four have beendiscussed. In all these scenarios the optimal drug regimen is proposed based ontwo methods. In the first method these medical interventions are modeled ascontrol interventions and a corresponding objective function and optimalcontrol problem is formulated. In this setting the optimal drug regimen isproposed. Later using the the comparative effectiveness method the optimal drugregimen is proposed based on basic reproduction number and viral load. Theaverage infected cell count and viral load decreased the most when all the fourinterventions were applied together. On the other hand the average susceptiblecell count decreased the best when Arbidol alone was administered. The basicreproduction number and viral count decreased the best when all the fourinterventions were applied together reinstating the fact obtained earlier inthe optimal control setting. These findings may help physicians with decisionmaking in treatment of life-threatening COVID-19 pneumonia.

Optimal Drug Regimen and Combined Drug Therapy and its Efficacy in the Treatment of COVID-19 : An Within-Host Modeling Study