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Object  This study demonstrates the applicability of semi-LASER localized dynamic$^{31}$P MRS to deeper lying areas of the exercising human soleus muscle (SOL).The effect of accurate localization and high temporal resolution on dataspecificity is investigated.  Materials and Methods To achieve high signal-to-noise ratio (SNR) at atemporal resolution of 6 s, a custom-built calf coil array was used at 7T. Thekinetics of phosphocreatine (PCr) and intracellular pH were quantifiedseparately in SOL and gastrocnemius medialis (GM) muscle of 9 volunteers,during rest, plantar flexion exercise and recovery.  Results  The average SNR of PCr at rest was 64$\pm$15 in SOL (83$\pm$12 in GM). Endexercise PCr depletion in SOL (19$\pm$9%) was far lower than in GM(74$\pm$14%). pH in SOL increased rapidly and, in contrast to GM, remainedelevated until the end of exercise.  Conclusion $^{31}$P MRS in single-shots every 6 s localized in the deeperlying SOL enabled quantification of PCr recovery times at low depletions and offast pH changes, like the initial rise. Both high temporal resolution andaccurate spatial localization improve specificity of Pi and thus pHquantification by avoiding multiple, and potentially indistinguishable sourcesfor changing Pi peak shape.

Localized Semi-LASER Dynamic 31P Magnetic Resonance Spectroscopy of the Soleus During and Following Exercise at 7 T