English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The geometric control of bone tissue growth plays a significant role in boneremodelling, age-related bone loss, and tissue engineering. However, howexactly geometry influences the behaviour of bone-forming cells remainselusive. Geometry modulates cell populations collectively through the evolvingspace available to the cells, but it may also modulate the individualbehaviours of cells. To factor out the collective influence of geometry andgain access to the geometric regulation of individual cell behaviours, wedevelop a mathematical model of the infilling of cortical bone pores and use itwith available experimental data on cortical infilling rates. Testing differentpossible modes of geometric controls of individual cell behaviours consistentwith the experimental data, we find that efficient smoothing of irregular poresonly occurs when cell secretory rate is controlled by porosity rather thancurvature. This porosity control suggests the convergence of a large scale ofintercellular signalling to single bone-forming cells, consistent with thatprovided by the osteocyte network in response to mechanical stimulus. Aftervalidating the mathematical model with the histological record of a realcortical pore infilling, we explore the infilling of a population of randomlygenerated initial pore shapes. We find that amongst all the geometricregulations considered, the collective influence of curvature on cell crowdingis a dominant factor for how fast cortical bone pores infill, and we suggestthat the irregularity of cement lines thereby explains some of the variabilityin double labelling data as well as the overall speed of osteon infilling.

Osteoblasts infill irregular pores under curvature and porosity controls: A hypothesis-testing analysis of cell behaviours