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The annual Plant and Animal Genome (PAG) Conference held in San Diego, 10th–14th January 2009, was a large meeting (2,300 participants) covering the diversity of science underpinning genome-level analyses in both the commercial and fundamental areas. The structure of the meeting was participant-driven through 105 workshops spread over 5 days. The conference was, as always, extremely well organized and included plenary lectures to define major issues and provide insights into the future directions of biotechnology in its broadest definition. This editorial is largely focused on the plenary lectures and is clearly a personal interpretation of the meeting and lectures, validated where possible using recent publications, and is not intended to imply approval from the PAG or presenters at the conference.

Diversity of genome research at the 2009 Plant and Animal Genome Conference