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Methanol is one of the most widely produced organic substrates from syngas and can serve as a bio-feedstock to cultivate acetogenic bacteria which allows a major contribution to reducing greenhouse gas.  Acetobacterium woodii  is one of the very few acetogens that can utilize methanol to produce acetate as sole product. Since  A. woodii  is genetically tractable, it is an interesting candidate to introduce recombinant pathways for production of bio-commodities from methanol. In this study, we introduced the butyrate production operon from a related acetogen,  Eubacterium callanderi  KIST612, into  A. woodii  and show a stable production of butyrate from methanol. This study also reveals how butyrate production by recombinant  A. woodii  strains can be enhanced with addition of electrons in the form of carbon monoxide. Our results not only show a stable expression system of non-native enzymes in  A. woodii  but also increase in the product spectrum of  A. woodii  to compounds with higher economic value.

Biosynthesis of butyrate from methanol and carbon monoxide by recombinant Acetobacterium woodii