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In our previous study, a marked association between Helicobacter pylori seropositivity and functional polymorphisms of the secretor and Lewis genes (odds ratio [OR], 0.32; 95% confidence interval [CI], 0.14-0.70 for se/se genotype relative to Se/Se genotype; and OR, 10.3; 95% CI, 3.16-33.8 for high-risk group defined by the combination of Se and Le relative to low-risk group) had been observed for 239 non-cancer Japanese outpatients of the gastroenterology clinic (OGC) undergoing gastroscopy at Aichi Cancer Center Hospital.

Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese