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Aflatoxin contamination of food and grain poses a serious economic and health problem globally. Aflatoxin B 1 (AFB 1 ) is extremely mutagenic and toxic as well as a potent carcinogen to both humans and livestock. In this study, the degradation of AFB 1 by extracellular extract of Cladosporium uredinicola was examined using high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), and liquid chromatography mass spectrometry. Within 24 h of incubation, AFB 1 was efficiently eliminated by the culture supernatant of C. uredinicola (84.5±5.7%) at 37°C; the elimination was proven to be enzymatic, and the enzyme was thermostable. The biotransformation products of AFB 1 detected by HPLC and TLC were proven to be the same compound. Analysis with LCMS showed that AFB 1 was bio-transformed to a structurally different compound (m/z=365 [M+Na] + ), which is first reported. The cytotoxicity study to HeLa cells indicated that culture supernatant-treated AFB 1 is less toxic as compared with AFB 1 .

Biotransformation and detoxification of aflatoxin B1 by extracellular extract of Cladosporium uredinicola