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Unbalanced differentiation of bone marrow cells into adipocytes rather than osteoblasts causes severe bone-related disorders, such as osteoporosis. Natural products that can act against unbalanced differentiation are targeted for development of functional dietary supplements. Limonium tetragonum , a halophyte known for anti-oxidant constituents, was studied for beneficial effects in prevention of adipogenesis of bone marrow stromal D1 cells in vitro . Solvent-partitioned extract fractions of L. tetragonum prevented differentiating D1 cells from accumulating lipids. Expression of the key adipogenic markers PPARγ, SREBP1c, and C/EBPα were inhibited at mRNA and protein levels. Suppressed protein levels of the phosphorylated MAPK-related factors ERK, JNK, and p-38 indicated inhibition of PPARγ pathway-linked adipogenesis in D1 cells. The n-BuOH fraction was the most effective fraction for bioactive substances. L. tetragonum inhibited adipogenesis in D1 bone marrow stromal cells due to the presence of bioactive flavonoids.

Adipogenesis inhibitory effects of Limonium tetragonum in mouse bone marrow stromal D1 cells