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Fucoidan is a sulfated polysaccharide that consists mainly of fucose and is found in brown seaweeds. In this study, fucoidan was extracted from Sargassum binderi (F sar ) from Malaysia and subsequently characterized in terms of composition, structure and toxicology. It was found that the molecular weight, polydispersity index, monosaccharide profile and degree of sulfation of F sar differed from those of commercial food-grade fucoidan (F ysk ). NMR analysis suggested that the main structure of F sar was →3)fuc-2-OSO 3  - (1→3)fuc-2-OSO 3  - (1→. A cytotoxicity study employing up to 200 mg/mL Sargassum binderi extract showed that cell inhibition was less than 50% (IC 50 ), while acute toxicity results classified S. binderi as category 5 (unclassified) according to the OECD Guideline 423, as no mortality was observed at the highest dosage (2,000 mg/kg). Both toxicity results showed that this material is safe to be consumed. The chemical characteristics and non-toxicity of F sar demonstrate its potential in biological and food product applications.

Chemical properties and toxicology studies of fucoidan extracted from Malaysian Sargassum binderi