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We argue that different aspects of Light-Front QCD at confined phase can berecovered by the Matrix Quantum Mechanics of D0-branes. The concerning MatrixQuantum Mechanics is obtained from dimensional reduction of pure Yang-Millstheory to 0+1 dimension. The aspects of QCD dynamics which are studied incorrespondence with D0-branes are: 1) phenomenological inter-quark potentials,2) whiteness of hadrons and 3) scattering amplitudes. In addition, some otherissues such as the large-N behavior, the gravity--gauge theory relation andalso a possible justification for involving ``non-commutative coordinates'' ina study of QCD bound-states are discussed.Comment: 26 pages, LaTeX file, 3 .eps figures; v2: language is improved; v3:  subsection 4.2 is changed- accepted for publication in EPJ.

D0-branes as light-front confined quarks