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Although 19F has high potential to serve as a background-free molecularmarker in bioimaging, the molar amount of marker substance is often too smallto enable 19F MR imaging or 19F NMR spectroscopy with a sufficiently highsignal-to-noise ratio (SNR). Hyperpolarization methods such asparahydrogen-based hyperpolarization or dynamic nuclear polarization (DNP) cansignificantly improve the SNR, but require expensive and complex samplepreparation and the removal of toxic catalysts and solvents. Therefore, we usedthe biologically compatible model of the fluorinated amino acid3-fluoro-DL-tyrosine with riboflavin 5'-monophosphate (FMN) as a chromophoredissolved in D2O with 3.4% H2Odest. allowing to transform light energy intohyperpolarization of the 19F nucleus via photo-chemically induced dynamicnuclear polarization (photo-CIDNP). We used a low-cost high-power blue LED toilluminate the sample replacing traditionally used laser excitation, which isboth potentially harmful and costly. For the first time, we present results ofhyperpolarized 19F MRI and 19F NMR performed with a low-cost 0.6 T benchtop MRIsystem. The device allowed simultaneous dual channel 1H/19F NMR. 19F imagingwas performed with a (0.94 mm)2 in-plane resolution. This enabled the spatialresolution of different degrees of hyperpolarization within the sample. Weestimated the photo-CIDNP-based 19F signal enhancement at 0.6 T to beapproximately 465. FMN did not bleach out even after multiple excitations, sothat the signal-to-noise ratio could be further improved by averaginghyperpolarized signals. The results show that the easy-to-use experimentalsetup has a high potential to serve as an efficient preclinical tool forhyperpolarization studies in bioimaging.

LED-based photo-CIDNP hyperpolarization enables 19F MR imaging and 19F NMR spectroscopy of 3-fluoro-DL-tyrosine at 0.6 T