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A variety of N '-[4-[(substituted imino)methyl]benzylidene]-substituted benzohydrazides have been synthesized and evaluated for antimicrobial and anticancer potential. Results from testing of antimicrobial activity indicated the most potent antimicrobial agents had p MIC  am  = 1.51. The synthesized compounds were bacteriostatic and fungistatic in action. Results from evaluation of antiviral activity indicated that none of the synthesized hydrazide derivatives inhibited viral replication at sub-toxic concentrations. Results from anti-HIV screening against HIV-2 strain ROD indicated that one compound was more potent ( IC  50  ≥ 1 μg/cm 3 ) than the standard drug nevirapine ( IC  50  ≥ 4 μg/cm 3 ) and another was equipotent ( IC  50  ≥ 4 μg/cm 3 ). The most effective anticancer agent against both HCT116 and MCF7 cancer cell lines had IC  50  = 19 and 18 μg/cm 3 , respectively. QSAR analysis indicated the importance of Wiener index ( W ) and energy of the lowest unoccupied molecular orbital (LUMO) in describing the antimicrobial activity of the synthesized compounds.

monatshefte für chemie

N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies