Open AccessThe impact of prolonged cold preservation on the graft function and gene expression levels in an experimental lung transplantation model
Author(s) -
Osamu Yoshida,
Masaomi Yamane,
S. Yamamoto,
Mikio Okazaki,
Shinichi Toyooka,
Takahiro Oto,
Yoshifumi Sano,
Shinichiro Miyoshi
Publication year - 2012
Publication title -
surgery today
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.655
H-Index - 63
eISSN - 1436-2813
pISSN - 0941-1291
DOI - 10.1007/s00595-012-0234-5
Subject(s) - medicine , lung transplantation , egr1 , transplantation , lung , ischemia , andrology , downregulation and upregulation , gene expression , real time polymerase chain reaction , immunology , pathology , gene , biology , biochemistry
Ischemia reperfusion injury (IRI) remains a significant cause of morbidity and mortality after lung transplantation. Early growth response-1 (EGR1) drives the expression of inflammatory mediators and has an important role in IRI. We hypothesized that the severe IRI caused by a long preservation induces a specific expression pattern of EGR1 and its target genes which would correlate with the lung graft function.
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