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Purpose To compare sociodemographic, health- and exercise-related characteristics of participants  vs.  decliners, and completers  vs.  drop-outs, in an exercise intervention trial during cancer treatment. Methods Patients with newly diagnosed breast, prostate, or colorectal cancer were invited to participate in a 6-month exercise intervention. Background data for all respondents ( n  = 2051) were collected at baseline by questionnaire and medical records. Additional data were collected using an extended questionnaire, physical activity monitors, and fitness testing for trial participants ( n  = 577). Moreover, a sub-group of decliners ( n  = 436) consented to additional data collection by an extended questionnaire . Data were analyzed for between-group differences using independent  t -tests and chi 2 -tests. Results Trial participants were younger (59 ± 12yrs  vs.  64 ± 11yrs,  p  &lt; .001), more likely to be women (80%  vs.  75%,  p  = .012), and scheduled for chemotherapy treatment (54%  vs.  34%,  p  &lt; .001), compared to decliners ( n  = 1391). A greater proportion had university education (60%  vs  40%,  p  &lt; .001), reported higher anxiety and fatigue, higher exercise self-efficacy and outcome expectations, and less kinesiophobia at baseline compared to decliners. A greater proportion of trial participants were classified as ‘not physically active’ at baseline; however, within the group who participated, being “physically active” at baseline was associated with trial completion. Completers ( n  = 410) also reported less kinesiophobia than drop-outs ( n  = 167). Conclusion The recruitment procedures used in comprehensive oncology exercise trials should specifically address barriers for participation among men, patients without university education and older patients. Individualized efforts should be made to enroll patients with low exercise self-efficacy and low outcome expectations of exercise. To retain participants in an ongoing exercise intervention, extra support may be needed for patients with kinesiophobia and those lacking health-enhancing exercise habits at baseline.

supportive care in cancer

Who makes it all the way? Participants vs. decliners, and completers vs. drop-outs, in a 6-month exercise trial during cancer treatment. Results from the Phys-Can RCT