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With a steadily increasing world population, humanity faces formidable challenges in securing commensurate food sources and increasing well being and life expectancy worldwide while at the same time mitigating environmental impacts and assuring reproductive rights to all. Reproductive biology generates important new knowledge necessary for more efficient food animal production, human reproductive health, voluntary, user-controlled birth/population control, prevention and management of sexually-transmitted diseases and science-based policymaking aimed at safeguarding and promoting new assisted reproductive therapies. Based on different fertility scenarios, the world population is projected to reach between 9.6 and 25 billion by the year 2050 (Jensen 2011). At the same time, HIV and other sexually-transmitted diseases (STD) remain a major concern with millions of new cases appearing every year, and the use of contraceptive technologies varies greatly between countries, regions and demographic categories (Friend and Doncel 2010). The present second special issue of Cell andTissue Research on reproduction offers a window into state-of-the-art cell biological/molecular approaches to study human and animal reproductive systems. Besides clinical research and research on rodent animals, studies employing large livestock animal models are reviewed prominently as the improvement of reproductive efficiency in food animals is increasingly predicted to drive world food supply

Reproductive systems biology tackles global issues of population growth, food safety and reproductive health