Open AccessOverexpression of E2F1 associated with LOH at RB locus and hyperphosphorylation of RB in non-small cell lung carcinoma
Author(s) -
Miwa Imai,
Yoshio Oda,
Makoto Oda,
Isao Nakanishi,
Ei Kawahara
Publication year - 2004
Publication title -
journal of cancer research and clinical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 94
eISSN - 1432-1335
pISSN - 0171-5216
DOI - 10.1007/s00432-003-0538-3
Subject(s) - e2f1 , biology , retinoblastoma protein , immunohistochemistry , retinoblastoma , microbiology and biotechnology , hyperphosphorylation , cancer research , loss of heterozygosity , cell cycle , tumor suppressor gene , gene , phosphorylation , carcinogenesis , genetics , allele , immunology
E2F1 plays a critical role in cell proliferation, and its function is controlled by the retinoblastoma (RB) protein. We examined the expression of E2F1 and the aberration of RB gene and protein to elucidate what factors contribute to the overexpression of E2F1 in non-small cell lung carcinomas.
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