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Resting-state functional connectivity (RSFC) has widely been used to examine reorganization of functional brain networks during normal aging. The extraction of generalizable age trends, however, is hampered by differences in methodological approaches, study designs and sample characteristics. Distinct age ranges of study samples thereby represent an important aspect between studies especially due to the increase in inter-individual variability over the lifespan. The current review focuses on comparing age-related differences in RSFC in the course of the whole adult lifespan versus later decades of life. We summarize and compare studies assessing age-related differences in within- and between-network RSFC of major resting-state brain networks. Differential effects of the factor age on resting-state networks can be identified when comparing studies focusing on younger versus older adults with studies investigating effects within the older adult population. These differential effects pertain to higher order and primary processing resting-state networks to a varying extent. Especially during later decades of life, other factors beyond age might come into play to understand the high inter-individual variability in RSFC.

Resting-state networks in the course of aging—differential insights from studies across the lifespan vs. amongst the old