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We read with interest the comments by Borhani-Haghighi and Safari, which corroborate the particular character of cerebral venous thrombosis (CVT) in Behçet’s disease (BD). The physiopathology of CVT in BD was beyond the scope of this article. However, we took your suggestion and reviewed in all the included studies the presence of venous infarction or intracranial hemorrhages, including hemorrhagic transformation. This information is presented in Table 1. As Borhani-Haghighi and Safari suspected these intracerebral lesions are absent in most of the cases of CVT in BD. The high frequency of extra-neurologic vascular events in patients with BD and CVT has been repeatedly highlighted, favoring the ‘‘vasculo-Behçet’’ hypothesis. Tunc et al. [1], and Wechsler et al. [2] found this association in 64% of patients with CVT, but only in 36% without CVT. Likewise, Al-Fahad and Al-Araji [3] reported that 55% patients who presented with intracranial hypertension (IH) had other venous thromboses, but this occurred only in 14% of patients with other neurological manifestations. This association was also referred to by Saadoun et al. [4]. However, this author also found that prothrombotic risk factors were present in one-third of patients with CVT and in most (56%) of those relapsing. The odds of thrombosis relapse was higher in those patients with a prothrombotic

Response to comment on “Cerebral venous thrombosis in Behcet’s disease: a systematic review” by Afshin Borhani-Haghighi and Anahid Safari