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A  Klebsiella pneumoniae  bacteriophage (vB_KpnM_IME346) was isolated from a hospital sewage sample. This bacteriophage specifically infects a clinical  K. pneumoniae  strain with a K63 capsular polysaccharide structure. The phage genome was evaluated by next-generation sequencing, which revealed a linear double-stranded DNA genome consisting of 49,482 base pairs with a G+C content of 49.1%. The latent period of vB_KpnM_IME346 was shown to be 20 min, and the burst size was 25–30 pfu (plaque-forming units)/infected cell. Transmission electron microscopy and phylogenetic analysis showed that the JD001-like phage belongs to the genus  Jedunavirus  of the family  Myoviridae . The newly isolated vB_KpnM_IME346 shows infectivity in the clinical host  K. pneumoniae  KP576 strain, indicating that it is a promising alternative to antibacterial agents for removing  K. pneumoniae  from patients.

Characterization and Genomic Analysis of Bacteriophage vB_KpnM_IME346 Targeting Clinical Klebsiella pneumoniae Strain of the K63 Capsular Type