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Manganese porphyrins are redox-active drugs and superoxide dismutase mimics, which have been shown to chemosensitize lymphoma, a cancer which frequently occurs in dogs. This study aimed to identify critical information regarding the pharmacokinetics and toxicity of Mn(III) meso-tetrakis (N-n-butoxyetylpyridium-2-yl) porphyrin, (MnTnBuOE-2-PyP 5+ , MnBuOE) in dogs as a prelude to a clinical trial in canine lymphoma patients.

Potential for a novel manganese porphyrin compound as adjuvant canine lymphoma therapy