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The pharmacokinetics (PK) of carfilzomib have been previously studied in multiple myeloma patients with varying degrees of renal impairment (normal, mild, moderate, severe, and end-stage renal disease [ESRD]) at doses of 15 and 20 mg/m 2 . This study evaluated carfilzomib PK at higher doses of 27 and 56 mg/m 2 in normal renal function and ESRD patients.

cancer chemotherapy and pharmacology

Pharmacokinetics and safety of carfilzomib in patients with relapsed multiple myeloma and end-stage renal disease (ESRD): an open-label, single-arm, phase I study