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Sorafenib and everolimus are both active against neuroendocrine tumors (NET). Because of potential synergy between VEGF pathway and mTOR inhibitors, we performed a phase I study to evaluate the safety and feasibility of combining sorafenib and everolimus in patients with advanced NET.

Phase I study of sorafenib in combination with everolimus (RAD001) in patients with advanced neuroendocrine tumors