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Poly-(gamma-L-glutamylglutamine)-paclitaxel (PGG-PTX) is a novel polymer-based formulation of paclitaxel (PTX) in which the PTX is linked to the polymer via ester bonds. PGG-PTX is of interest because it spontaneously forms very small nanoparticles in plasma. In mouse models, PGG-PTX increased tumor exposure to PTX by 7.7-fold relative to that produced by PTX formulated in Cremophor. In this study, the efficacy of PGG-PTX was compared to that of Abraxane, an established nanoparticular formulation of PTX, in three different tumor models.

Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane