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Femoral and patellar cartilage defects with a defect size &gt; 2.5 cm 2 are a potential indication for an autologous chondrocyte implantation (ACI). However, the influence of the localization and the absolute and relative defect size on the clinical outcome has not yet been determined. The purpose of this study is to analyze the influence of the localization and the absolute and relative defect size on the clinical outcome after third-generation autologous chondrocyte implantation.

Effect of the defect localization and size on the success of third-generation autologous chondrocyte implantation in the knee joint