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Perfusion-weighted MRI (PWI) and O-(2-[ 18 F]fluoroethyl-)-l-tyrosine ([ 18 F]FET) PET are both applied to discriminate tumor progression (TP) from treatment-related changes (TRC) in patients with suspected recurrent glioma. While the combination of both methods has been reported to improve the diagnostic accuracy, the performance of a sequential implementation has not been further investigated. Therefore, we retrospectively analyzed the diagnostic value of consecutive PWI and [ 18 F]FET PET.

european journal of nuclear medicine and molecular imaging

Sequential implementation of DSC-MR perfusion and dynamic [18F]FET PET allows efficient differentiation of glioma progression from treatment-related changes