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Tumour blood flow (TBF) is a crucial determinant of cancer growth. Recently, we validated Rubidium-82 ( 82 Rb) positron emission tomography (PET) for TBF measurement in prostate cancer (PCa) and found TBF and cancer aggressiveness positively correlated. The aims of the present study were to determine the ability of TBF for separating significant from insignificant PCa and to examine the relation to underlying Na + /K + -ATPase density, which is relevant as 82 Rb is transported intracellularly via the Na + /K + -ATPase.

Tumour blood flow for prediction of human prostate cancer aggressiveness: a study with Rubidium-82 PET, MRI and Na+/K+-ATPase-density