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As an alternative to technetium-99m-macroaggregated albumin ( 99m Tc-MAA), a scout dose of holmium-166 ( 166 Ho) microspheres can be used prior to 166 Ho-radioembolization. The use of identical particles for pre-treatment and treatment procedures may improve the predictive value of pre-treatment analysis of distribution. The aim of this study was to analyze the agreement between 166 Ho-scout and 166 Ho-therapeutic dose in comparison with the agreement between 99m Tc-MAA and 166 Ho-therapeutic dose.

european journal of nuclear medicine and molecular imaging

The superior predictive value of 166Ho-scout compared with 99mTc-macroaggregated albumin prior to 166Ho-microspheres radioembolization in patients with liver metastases