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Amino acid-based tracers have been extensively investigated for positron emission tomography (PET) imaging of brain tumors, and 11 C-methionine ( 11 C-MET) is one of the most extensively investigated. However, widespread clinical use of 11 C-MET is challenging due to the short half-life of 11 C and low radiolabeling yield. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Yang and colleagues report an 18 F-labeled boron-derived methionine analog, 18 F-B-MET, as a potential substitute for 11 C-MET in PET imaging of glioma. The push-button synthesis, highly efficient radiolabeling, and good imaging performance in glioma models make this tracer a promising candidate for future clinical translation.

One-step synthesis of an 18F-labeled boron-derived methionine analog: a substitute for 11C-methionine?