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Osteoclast activity is an important factor in the pathogenesis of skeletal metastases and is a potential therapeutic target. This study aimed to determine if selective uptake of 99m Tc-maraciclatide, a radiopharmaceutical targeting α v β 3 integrin, occurs in prostate cancer (PCa) bone metastases and to observe the changes following systemic therapy.

european journal of nuclear medicine and molecular imaging

Imaging αvβ3 integrin expression in skeletal metastases with 99mTc-maraciclatide single-photon emission computed tomography: detection and therapy response assessment