English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Dear Sir, We read with great interest the letter from Laffon et al. [1] in which the authors refer to a recently published paper of our group that evaluates the factors affecting 2-deoxy-2-(F)fluoro-D-glucose (F-FDG) uptake in the liver and mediastinum during chemotherapy (CHT) in Hodgkin’s lymphoma (HL) [2]. Laffon et al. suggest that the total amount of uptake in malignant tissues of cancer patients may play a role in the reduction of F-FDG uptake in the liver at staging in HL (as shown in the report previously cited) [2, 3]. For this reason, the authors suggest that the measurement of the total F-FDG that is irreversibly trapped in a pathological tissue (as measured by a formula suggested by Laffon et al. [3]) could help in the explanation of this phenomenon and could be useful when evaluating positron emission tomography/computed tomography (PET/CT) scans of patients with cancer. We agree with the hypothesis of Laffon and colleagues. We performed a further analysis of the data already published [2], and here we report a graphical representation of the relationship between the maximum standardized uptake value (SUVmax) in the mediastinum and the stage of the disease (Fig. 1) that led to results similar to those observed in the liver [2]. In particular, in our study cohort, the SUVmax in the mediastinum is significantly related to the extension of HL according to Ann Arbor criteria with a lower SUVmax in the mediastinum being related to a higher stage of the disease (p= 0.0385, Fig. 1) [2]. In agreement with Laffon et al., we can conclude that when a tissue shows an intense tracer uptake, the amount of tracer available to another tissue is reduced (to be specific, the circulating F-FDG in the blood as detectable by means of mediastinum SUVmax) [4]. We would like to thank Laffon et al. for their detailed comments and suggestions that have greatly improved the results of our study.

european journal of nuclear medicine and molecular imaging

Reply to comments by Laffon et al.: Liver SUV versus stage in Hodgkin’s lymphoma: the total amount of uptake may play a role in the inverse relationship