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Accurate diagnosis and management of skeletal infectionis crucial and challenging. The goals of imaging ininfection are (a) to establish an early and reliable diag-nosis, as clinical and laboratory markers are often non-specific in the early stages, (b) to localize, characterizeand define the extent of involvement (often influences ordirects diagnostic and/or therapeutic intervention), and (c)to assess treatment response [1]. Such considerations areparticularly important in several select groups of patientssuch as diabetics, who are relatively more prone tocutaneous ulceration and its related complications. Ap-proximately 2 million cases of musculoskeletal infectionare diagnosed each year in the USA [2] and MRI is themost commonly used imaging modality. MRI with gado-linium contrast enhancement is useful (a) in differentiat-ing abscess from inflammatory tissue, (b) to differentiateviable from nonviable tissue, and (c) to evaluate boneinvolvement [1]. However, the presence of preexistingrenal impairment is a potentially major limitation in theuse of MRI with gadolinium contrast enhancement. Metalartefacts may obscure underlying pathology, if there hasbeen previous intervention [1] and it may be difficult todistinguish osteomyelitis from Charcot’s neuroarthropathyin the diabetic foot using MRI alone.Radionuclide imaging plays an important role in theevaluation of infection and most would agree that radio-labelled leukocyte imaging remains a key investigation inthe assessment of infection and in particular fever of un-known origin (FUO), vascular graft infections, orthopaedicinfections and infections complicating the diabetic foot [3,4]. Despite advances in imaging techniques, and newertracers, it has not been possible to achieve 100 % accuracyin diagnosis, but the goal remains.In the current issue of the European Journal of NuclearMedicine and Molecular Imaging, Kagna et al. present theirresults assessing the role of

Diagnosis of infection in the diabetic foot using 18F‐FDG PET/CT: a sweet alternative?