English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

To the Editor, We read with interest the article ‘‘Assessment of EarlyOnset Chronic Progressive Anthracycline Cardiotoxicity in Children: Different Response Patterns of Right and Left Ventricles’’ from Kocabas et al. [2]. In our opinion, this is an excellent article describing the effect of cumulative dose on left-ventricular (LV) and right-ventricular (RV) function in pediatric patients receiving cancer treatment using tissue Doppler imaging (TDI) parameters. The importance of TDI measurements of LV and RV function in the process of dose evaluation of anthracycline treatment has also been described to be a clinically useful technique for the assessment of LV and RV function [1]. Kocabas et al. [2] clearly state that abnormalities of RV and the LV function were observed even with a cumulative anthracycline dose \120 mg/m. They also found that the tricuspid annular peak systolic velocity (S0) was significantly lower in a patient group receiving anthracycline at doses[240 mg/m than those observed in a control group. In accordance with the findings of Kocabas et al. [2], the impairment of RV and LV function after anthracycline treatment using cardiac magnetic resonance imaging has also been described in long-term survivors of childhood cancer [4]. For the convenience of the readership of Pediatric Cardiology, we add that recently our group published normal S0 values with z-scores for healthy pediatric patients [3]. Given these available normal values, the investigators would have been able to compare the measured S0 values of their patients with respective age-related normal z-score values and not only with those of a small control group. This comparison probably would have improved the statistical power of their analysis, although we must state that the normal values for this age group are close to adult normal values. The remarkable study from Kocabas et al. [2] clearly supports the notion that the right ventricle is susceptible to anthracycline in pediatric cancer patients. We thank the investigators for addressing the need for careful and systematic evaluation of both RV and LV function in the context of the need of cancer treatment with anthracycline in children and look forward for more interesting studies from this group.

pediatric cardiology

Relevance of Tricuspid Annular Peak Systolic Velocity (S′) to Detect Systolic Right-Ventricular Impairment After Anthracycline Cancer Treatment in Childhood