Open AccessTPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients
Author(s) -
Mateusz Kurzawski,
Krzysztof Dziewanowski,
Agnieszka Lener,
Marek Droździk
Publication year - 2009
Publication title -
european journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.845
H-Index - 108
eISSN - 1432-1041
pISSN - 0031-6970
DOI - 10.1007/s00228-009-0630-y
Subject(s) - itpa , thiopurine methyltransferase , azathioprine , genotype , medicine , pharmacogenetics , gastroenterology , transplantation , gene polymorphism , pharmacology , immunology , biology , genetics , gene , disease , ribavirin
Thiopurine drugs have to be withdrawn in 10-30% of cases due to side effects, and it has been presented that genetic factors may be responsible for some of reported toxicity cases. Among polymorphic enzymes of thiopurines' metabolic pathway, thiopurine S-methyltransferase (TPMT) has been studied most extensively, and some recent studies point to inosine triphosphate pyrophosphohydrolase (ITPA) polymorphism as an additional toxicity risk factor.
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