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Accumulating evidence shows that the serotonergic system plays a major role in psychostimulant abuse through its interactions with the dopaminergic system. Studies indicate that serotonin 5-HT 2C receptors are one of the main classes of receptors involved in mediating the influence of serotonin in drug abuse.

psychopharmacology/psychopharmacologia

Effects of the serotonin 2C receptor agonist WAY163909 on the abuse-related effects and mesolimbic dopamine neurochemistry induced by abused stimulants in rhesus monkeys